Title: Interaction Effect between 5-HTTLPR and HTR1A RS6295 Polymorphisms on the Frontoparietal Network
Authors: Long, HX; Liu, B; Wang, C; Zhang, XL; Li, J; Yu, CS; Jiang, TZ
Author Full Names: Long, Haixia; Liu, Bing; Wang, Chao; Zhang, Xiaolong; Li, Jin; Yu, Chunshui; Jiang, Tianzi
Source: NEUROSCIENCE, 362 239-247; 10.1016/j.neuroscience.2017.08.003 OCT 24 2017
Language: English
Abstract: Previous studies have shown a close relationship between the serotonin system and working memory (WM), but the neural mechanism for the role of the serotonin system on the WM is unclear. The frontoparietal network is involved in WM and is associated with the serotonin system. Therefore, this study investigated the interaction effect of the serotonin transporter-linked polymorphic region (5-HTTLPR) and the polymorphism in the serotonin 1A receptor gene (rs6295) on the frontoparietal network obtained from the independent component analysis in a large, young Chinese sample population. The current study found a significant interaction effect of 5-HTTLPR and rs6295 on the connectivity within the right frontoparietal network, specifically in the middle frontal gyrus and inferior parietal lobule. Moreover, the mean connectivity in the right inferior parietal lobule was positively correlated with WM performance. These brain network analysis findings could provide a new perspective on the neural mechanisms of gene-gene interactions and on individual differences in cognitive functions. (C) 2017 Published by Elsevier Ltd on behalf of IBRO.
ISSN: 0306-4522
eISSN: 1873-7544
IDS Number: FJ0EU
Unique ID: WOS:000412382100021
PubMed ID: 28793232