Title: Identifying the White Matter Impairments Among ART-na < ve HIV Patients: A Multivariate Pattern Analysis of DTI Data
|
| Authors: Tang, ZC; Liu, ZY; Li, RL; Yang, X; Cui, XW; Wang, S; Yu, DD; Li, HJ; Dong, EQ; Tian, J
|
| Author Full Names: Tang, Zhenchao; Liu, Zhenyu; Li, Ruili; Yang, Xin; Cui, Xingwei; Wang, Shuo; Yu, Dongdong; Li, Hongjun; Dong, Enqing; Tian, Jie
|
| Source: EUROPEAN RADIOLOGY, 27 (10):4153-4162; 10.1007/s00330-017-4820-1 OCT 2017
|
| Language: English
|
| Abstract: To identify the white matter (WM) impairments of the antiretroviral therapy (ART)-na < ve HIV patients by conducting a multivariate pattern analysis (MVPA) of Diffusion Tensor Imaging (DTI) data We enrolled 33 ART-na < ve HIV patients and 32 Normal controls in the current study. Firstly, the DTI metrics in whole brain WM tracts were extracted for each subject and feed into the Least Absolute Shrinkage and Selection Operators procedure (LASSO)-Logistic regression model to identify the impaired WM tracts. Then, Support Vector Machines (SVM) model was constructed based on the DTI metrics in the impaired WM tracts to make HIV-control group classification. Pearson correlations between the WM impairments and HIV clinical statics were also investigated. Extensive HIV-related impairments were observed in the WM tracts associated with motor function, the corpus callosum (CC) and the frontal WM. With leave-one-out cross validation, accuracy of 83.08% (P=0.002) and the area under the Receiver Operating Characteristic curve of 0.9110 were obtained in the SVM classification model. The impairments of the CC were significantly correlated with the HIV clinic statics. The MVPA was sensitive to detect the HIV-related WM changes. Our findings indicated that the MVPA had considerable potential in exploring the HIV-related WM impairments. aEuro cent WM impairments along motor pathway were detected among the ART-na < ve HIV patients aEuro cent Prominent HIV-related WM impairments were observed in CC and frontal WM aEuro cent The impairments of CC were significantly related to the HIV clinic statics aEuro cent The CC might be susceptible to immune dysfunction and HIV replication aEuro cent Multivariate pattern analysis had potential for studying the HIV-related white matter impairments.
|
| ISSN: 0938-7994
|
| eISSN: 1432-1084
|
| IDS Number: FF4UJ
|
| Unique ID: WOS:000408952400018
*Click Here to View Full Record
