Title: Thermally Triggered in Situ Assembly of Gold Nanoparticles for Cancer Multimodal Imaging and Photothermal Therapy
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| Authors: Sun, MM; Peng, D; Hao, HJ; Hu, J; Wang, DL; Wang, K; Liu, J; Guo, XM; Wei, Y; Gao, WP
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| Author Full Names: Sun, Mengmeng; Peng, Don; Hao, Hanjun; Hu, Jin; Wang, Dongliang; Wang, Kun; Liu, Jing; Guo, Ximin; Wei, Yen; Gao, Weiping
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| Source: ACS APPLIED MATERIALS & INTERFACES, 9 (12):10453-10460; 10.1021/acsami.6b16408 MAR 29 2017
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| Language: English
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| Abstract: The assembly of gold nanoparticles (AuNPs) to AuNP assemblies is of interest for cancer therapy and imaging. Herein we introduce a new and general paradigm, thermally triggered AuNP assembly, for the development of novel intelligent platforms for cancer photothermal therapy (PTT) and multimodal imaging. Site-specific conjugation of a thermally sensitive elastin-like polypeptide (ELP) to AuNPs yields thermally sensitive ELP-AuNPs. Interestingly, ELP-AuNPs can in situ form AuNP assemblies composed of short necklace-like gold nanostructures at elevated temperatures and thus show strong near-infrared light absorption and high photothermal effect. These thermally responsive properties of ELP-AuNPs enable simultaneous photothermal/photoacoustic/X-ray computed tomographic imaging and PTT of melanoma after single intratumoral injection of ELP-AuNPs. The thermally triggered assembly of a variety of nanoparticles with optical, electronic, and magnetic properties into nanoparticle assemblies may open new ways for the establishment of intelligent platforms for various applications in biomedicine.
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| ISSN: 1944-8244
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| IDS Number: EQ7EQ
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| Unique ID: WOS:000398246900017
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| PubMed ID: 28271705
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