Title: 12 H Abstinence-induced Right Anterior Insula Network Pattern Changes in Young Smokers
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| Authors: Bi, YZ; Zhang, YJ; Li, YD; Yu, DH; Yuan, K; Tian, J
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| Author Full Names: Bi, Yanzhi; Zhang, Yajuan; Li, Yangding; Yu, Dahua; Yuan, Kai; Tian, Jie
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| Source: DRUG AND ALCOHOL DEPENDENCE, 176 162-168; 10.1016/j.drugalcdep.2017.02.019 JUL 1 2017
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| Language: English
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| Abstract: Background: The strong craving to smoke is a core factor of smoking abstinence that precipitates relapse. Insula plays critical roles in maintaining nicotine dependence, especially in the interoceptive awareness of craving. Despite evidence indicating a link between insula and abstinence-induced craving, less is known about the neural basis of abstinence-induced craving from the circuit level of insula. Methods: The present study examined the effects of 12 h of abstinence from smoking on the resting state functional connectivity (RSFC) of anterior (AI) and posterior insula in young smokers using a within-subject design. Thirty-three young male smokers underwent functional magnetic resonance imaging scanning on two separate sessions: (1) smoking satiety and (2) abstinence (after 12 h of smoking deprivation), in counterbalanced order. Multiple regression analysis was applied to investigate the possible relationships between the RSFC changes of insula (abstinence minus satiety) and the abstinence-induced craving changes. Results: Smoking abstinence state (versus satiety) was associated with increased RSFC between right AI and right medial orbitofrontal cortex (OFC), ventromedial prefrontal cortex as well as anterior cingulate cortex. The abstinence-induced RSFC changes between right AI and right lateral OFC was significantly correlated with the craving changes. Conclusions: These findings improve the understanding of the effects of short-term smoking abstinence on insula circuit connectivity and may contribute new insights into the neural basis of abstinence-induced craving to smoke.
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| ISSN: 0376-8716
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| eISSN: 1879-0046
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| IDS Number: EZ1VG
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| Unique ID: WOS:000404498300023
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| PubMed ID: 28544994
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