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Noninvasive Amide Proton Transfer Magnetic Resonance Imaging in Evaluating the Grading and Cellularity of Gliomas
Mar 29, 2017Author:
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Title: Noninvasive Amide Proton Transfer Magnetic Resonance Imaging in Evaluating the Grading and Cellularity of Gliomas  

Authors: Bai, Y; Lin, YS; Zhang, W; Kong, LF; Wang, LF; Zuo, PL; Vallines, I; Schmitt, B; Tian, J; Song, XL; Zhou, JY; Wang, MY 

Author Full Names: Bai, Yan; Lin, Yusong; Zhang, Wei; Kong, Lingfei; Wang, Lifu; Zuo, Panli; Vallines, Ignacio; Schmitt, Benjamin; Tian, Jie; Song, Xiaolei; Zhou, Jinyuan; Wang, Meiyun 

Source: ONCOTARGET, 8 (4):5834-5842; 10.18632/oncotarget.13970 2017  

Language: English 

Abstract: Using noninvasive magnetic resonance imaging techniques to accurately evaluate the grading and cellularity of gliomas is beneficial for improving the patient outcomes. Amide proton transfer imaging is a noninvasive molecular magnetic resonance imaging technique based on chemical exchange saturation transfer mechanism that detects endogenous mobile proteins and peptides in biological tissues. Between August 2012 and November 2015, a total number of 44 patients with pathologically proven gliomas were included in this study. We compared the capability of amide proton transfer magnetic resonance imaging with that of noninvasive diffusion-weighted imaging and noninvasive 3-dimensional pseudo-continuous arterial spin imaging in evaluating the grading and cellularity of gliomas. Our results reveal that amide proton transfer magnetic resonance imaging is a superior imaging technique to diffusion-weighted imaging and 3-dimensional pseudo-continuous arterial spin imaging in the grading of gliomas. In addition, our results showed that the Ki-67 index correlated better with the amide proton transfer-weighted signal intensity than with the apparent diffusion coefficient value or the cerebral blood flow value in the gliomas. Amide proton transfer magnetic resonance imaging is a promising method for predicting the grading and cellularity of gliomas. 

ISSN: 1949-2553  

IDS Number: EJ5WG  

Unique ID: WOS:000393289000036 

PubMed ID: 27992380  

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